Assessment of inflammatory markers in otosclerosis patients

Abstract Introduction Otosclerosis is an idiopathic disease characterized by new bone formation in foci of the human otic capsule. It is more common in Caucasian populations; affecting females twice as often as males. Its etiopathogenesis has not yet been fully elucidated. Objective The aim of this study was to investigate the relationship between otosclerosis and white blood cell and thrombocyte counts, mean platelet volume, neutrophil lymphocyte ratio, and the platelet lymphocyte ratio. Methods This retrospective case-control study was conducted in the outpatient clinic Mustafa Kemal University, in the department of otolaryngology, between 2015 and 2018. A total of 30 patients with an established diagnosis of otosclerosis were compared to a control group of 30 healthy subjects, matched for age, gender and body mass index. The white blood cell, thrombocyte, mean platelet volume, neutrophil lymphocyte ratio and platelet lymphocyte ratio values were calculated for all participants. Results There was no statistically significant difference between the groups with respect to age, gender, or body mass index, or for the mean neutrophil lymphocyte ratio, platelet lymphocyte ratio, white blood cell, or thrombocyte values (p > 0.05). A statistically significant difference was determined between the groups for the mean platelet volume values. The mean platelet volume values were lower in the otosclerotic patients (p = 0.047). Conclusion These results show that neutrophil lymphocyte ratio, platelet lymphocyte ratio, white blood cell and thrombocytes should not be used to predict otosclerosis, but suggest that mean platelet volume may be a negative predictive marker.

【摘要】引言：耳硬化症（otosclerosis）是一类以人类耳囊病灶处新骨形成为特征的特发性疾病，在高加索人群中更为高发，女性发病率为男性的两倍，其发病机制尚未完全阐明。目的：本研究旨在探讨耳硬化症与白细胞计数、血小板计数、平均血小板体积（mean platelet volume）、中性粒细胞淋巴细胞比值及血小板淋巴细胞比值之间的关联。方法：本回顾性病例对照研究于2015至2018年间在穆斯塔法·凯末尔大学（Mustafa Kemal University）耳鼻喉科门诊开展，共纳入经确诊的耳硬化症患者30例，并选取年龄、性别、体质量指数（body mass index）匹配的30名健康受试者作为对照组，对所有受试者的白细胞计数、血小板计数、平均血小板体积、中性粒细胞淋巴细胞比值及血小板淋巴细胞比值进行统计计算。结果：两组在年龄、性别、体质量指数，以及中性粒细胞淋巴细胞比值、血小板淋巴细胞比值、白细胞计数、血小板计数方面的差异均无统计学意义（p > 0.05）；两组的平均血小板体积值存在统计学差异，耳硬化症患者的平均血小板体积值更低（p = 0.047）。结论：本研究结果表明，中性粒细胞淋巴细胞比值、血小板淋巴细胞比值、白细胞计数及血小板计数无法用于预测耳硬化症，但提示平均血小板体积或可作为一项阴性预测标志物。