Post-slippage cells increase expression of factors associated with SASP.

Human transcriptome analysis of U2OS cells treated with nocodazole or DMSO (Control). The gene expression profiling will reveal senescence-associated genes induced upon nocodazole treatment. Our preliminary data show that antimitotic drugs treatment promote post-slippage senescence. We analyzed RNA samples extracted from treated cells using the Affymetrix Human Transcriptome 2.0 Arrays. Array data was processed by Partak genomic suite software. Two biological replicates were performed.