Effect of the consumption on buriti oil on the metabolism of rats induced by iron overload

Objectives To compare the effect of the consumption of buriti oil and soybean oil on the metabolism of rats under stress induced by iron overload.Materials and methods A total of 28 rats were randomized into control groups who consumed diet added of soybean (CS) or buriti oil (CB) and gavage with saline and two experimental groups who consumed diet added of soybean (ES) or buriti oil (EB) and daily gavage with iron II sulfate as stress inducer. The fatty acid profile of diets was analyzed. Body weight and diet consumption were evaluated every two days. The lipid profile and liver weight of animals were evaluated at the end of the experiment.Results Diet added of soybean oil showed higher percentage of polyunsaturated fatty acids (45.6%) and diet with buriti oil was rich in monounsaturated fatty acids (66.9%). There were no differences in food intake, total cholesterol, HDL-cholesterol and LDL-cholesterol among groups (p > 0.05). However, animals fed with diet supplemented with buriti oil showed intermediate triglyceride levels (CB: 65 mg/dL; EB: 68.7 mg/dL) compared to ES group (102.5 mg/dL). The liver of rats from the CS group had higher weight (2.06 ± 0.2 g) compared to the CB group (1.56 ± 0.1 g).Conclusion Buriti oil consumption was able to minimize some changes related to iron overload.

### 研究目的
对比摄入布里蒂油（buriti oil）与大豆油（soybean oil）对铁过载诱导应激状态下大鼠代谢的影响。

### 材料与方法
共选取28只大鼠，随机分为4组：2个对照组分别饲喂添加大豆油（CS组）或布里蒂油（CB组）的日粮，并每日灌服生理盐水；2个实验组分别饲喂添加大豆油（ES组）或布里蒂油（EB组）的日粮，并每日灌服硫酸亚铁(II)以构建铁过载应激模型。对日粮的脂肪酸谱进行分析；每两日监测一次大鼠体重与日粮摄入量；实验结束后检测各组大鼠的血脂指标与肝脏重量。

### 实验结果
添加大豆油的日粮多不饱和脂肪酸占比更高（45.6%），而添加布里蒂油的日粮则富含单不饱和脂肪酸（66.9%）。各组大鼠的摄食量、总胆固醇、高密度脂蛋白胆固醇（HDL-cholesterol）与低密度脂蛋白胆固醇（LDL-cholesterol）水平均无显著统计学差异（p > 0.05）。但与ES组（102.5 mg/dL）相比，饲喂布里蒂油日粮的CB组（65 mg/dL）与EB组（68.7 mg/dL）大鼠的甘油三酯水平处于中间区间。CS组大鼠的肝脏重量（2.06 ± 0.2 g）显著高于CB组（1.56 ± 0.1 g）。

### 研究结论
摄入布里蒂油可减轻铁过载相关的部分代谢改变。