Additional file 1 of Mass spectrometry-based proteomics profiling of dogs with and without oral diseases: a systematic review

Supplementary Material 1: Supplementary Table 1: List of the most abundant proteins reported in the included studies. Green highlight represents the most abundant proteins found in healthy dogs; Orange highlight represents the most abundant proteins found in healthy dogs and dogs with periodontal diseases; Yellow highlight represents the most abundant proteins found in dogs with benign oral tumors; Light blue highlight represents the most abundant proteins found in dogs with early-stage oral melanoma; Purple highlight represents the most abundant proteins found in dogs with late-stage oral melanoma; Red highlight represents the most abundant proteins found in dogs with oral squamous cell carcinoma; Grey highlight represents the most abundant proteins found in dogs with periodontal diseases, benign oral tumors, early-stage oral melanoma; late-stage oral melanoma, and oral squamous cell carcinoma; Dark red highlight represents the most abundant proteins found in dogs with dental calculus; Light blue highlight represents the most abundant proteins found in dogs with mixed cancers; and Orange red highlight represents the most abundant proteins found in dogs with periodontal diseases.Supplementary Table 2: List of names of all breeds of dogs used in the included studies along with the number of dogs used. Supplementary Table 3: Gene Ontology analysis – biological processes of the most abundant proteins among healthy dogs identified in the included studies. Supplementary Table 4: Gene Ontology analysis – cellular compartments of the most abundant proteins among healthy dogs identified in the included studies.Supplementary Table 5: Gene Ontology analysis – molecular functions of the most abundant proteins among healthy dogs identified in the included studies. Supplementary Table 6: KEGG pathway analysis of the most abundant proteins among healthy dogs identified in the included studies. Supplementary Table 7: Gene Ontology analysis – biological processes of the most abundant proteins among periodontitis dogs identified in the included studies. Supplementary Table 8: Gene Ontology analysis – cellular compartments of the most abundant proteins among periodontitis dogs identified in the included studies. Supplementary Table 9: Gene Ontology analysis – molecular functions of the most abundant proteins among periodontitis dogs identified in the included studies. Supplementary Table 10: KEGG pathway analysis of the most abundant proteins among periodontitis dogs identified in the included studies. Supplementary Table 11: Gene Ontology analysis – biological processes of the most abundant proteins among dogs with calculus identified in the included studies. Supplementary Table 12: Gene Ontology analysis – cellular compartments of the most abundant proteins among dogs with calculus identified in the included studies.Supplementary Table 13: Gene Ontology analysis – molecular functions of the most abundant proteins among dogs with calculus identified in the included studies.Supplementary Table 14: KEGG pathway analysis of the most abundant proteins among dogs with calculus identified in the included studies.Supplementary Table 15: Gene Ontology analysis – biological processes of the most abundant proteins among dogs with oral tumors identified in the included studies.Supplementary Table 16: Gene Ontology analysis – cellular compartments of the most abundant proteins among dogs with oral tumors identified in the included studies.Supplementary Table 17: Gene Ontology analysis – molecular functions of the most abundant proteins among dogs with oral tumors identified in the included studies.Supplementary Table 18: Protein-Protein interactions analysis of the most abundant proteins among healthy dogs identified in the included studies. Supplementary Table 19: Protein-Protein interactions analysis of the most abundant proteins among dogs with calculus identified in the included studies. Supplementary Table 20: Protein-Protein interactions analysis of the most abundant proteins among periodontitis dogs identified in the included studies. Supplementary Table 21: Protein-Protein interactions analysis of the most abundant proteins among dogs with oral tumors identified in the included studies.

补充材料1：补充表1：纳入研究中报道的丰度最高蛋白质列表。绿色高亮代表健康犬中检出的丰度最高蛋白质；橙色高亮代表健康犬与牙周病犬中均检出的丰度最高蛋白质；黄色高亮代表口腔良性肿瘤犬中检出的丰度最高蛋白质；浅蓝色高亮代表早期口腔黑色素瘤犬中检出的丰度最高蛋白质；紫色高亮代表晚期口腔黑色素瘤犬中检出的丰度最高蛋白质；红色高亮代表口腔鳞状细胞癌犬中检出的丰度最高蛋白质；灰色高亮代表牙周病、口腔良性肿瘤、早期口腔黑色素瘤、晚期口腔黑色素瘤及口腔鳞状细胞癌犬中均检出的丰度最高蛋白质；暗红色高亮代表牙结石犬中检出的丰度最高蛋白质；浅蓝色高亮代表混合性癌症犬中检出的丰度最高蛋白质；橙红色高亮代表牙周病犬中检出的丰度最高蛋白质；补充表2：纳入研究中使用的所有犬品种名称及对应实验犬数量列表；补充表3：基因本体论（Gene Ontology）分析——纳入研究中鉴定的健康犬丰度最高蛋白质的生物学过程条目；补充表4：基因本体论分析——纳入研究中鉴定的健康犬丰度最高蛋白质的细胞组分条目；补充表5：基因本体论分析——纳入研究中鉴定的健康犬丰度最高蛋白质的分子功能条目；补充表6：京都基因与基因组百科全书通路（KEGG pathway）分析——纳入研究中鉴定的健康犬丰度最高蛋白质的通路富集结果；补充表7：基因本体论分析——纳入研究中鉴定的牙周炎犬丰度最高蛋白质的生物学过程条目；补充表8：基因本体论分析——纳入研究中鉴定的牙周炎犬丰度最高蛋白质的细胞组分条目；补充表9：基因本体论分析——纳入研究中鉴定的牙周炎犬丰度最高蛋白质的分子功能条目；补充表10：京都基因与基因组百科全书通路分析——纳入研究中鉴定的牙周炎犬丰度最高蛋白质的通路富集结果；补充表11：基因本体论分析——纳入研究中鉴定的牙结石犬丰度最高蛋白质的生物学过程条目；补充表12：基因本体论分析——纳入研究中鉴定的牙结石犬丰度最高蛋白质的细胞组分条目；补充表13：基因本体论分析——纳入研究中鉴定的牙结石犬丰度最高蛋白质的分子功能条目；补充表14：京都基因与基因组百科全书通路分析——纳入研究中鉴定的牙结石犬丰度最高蛋白质的通路富集结果；补充表15：基因本体论分析——纳入研究中鉴定的口腔肿瘤犬丰度最高蛋白质的生物学过程条目；补充表16：基因本体论分析——纳入研究中鉴定的口腔肿瘤犬丰度最高蛋白质的细胞组分条目；补充表17：基因本体论分析——纳入研究中鉴定的口腔肿瘤犬丰度最高蛋白质的分子功能条目；补充表18：蛋白质相互作用（Protein-Protein interactions）分析——纳入研究中鉴定的健康犬丰度最高蛋白质的互作网络结果；补充表19：蛋白质相互作用分析——纳入研究中鉴定的牙结石犬丰度最高蛋白质的互作网络结果；补充表20：蛋白质相互作用分析——纳入研究中鉴定的牙周炎犬丰度最高蛋白质的互作网络结果；补充表21：蛋白质相互作用分析——纳入研究中鉴定的口腔肿瘤犬丰度最高蛋白质的互作网络结果