mRNA-1273 but not BNT162b2 induces antibodies against polyethylene glycol (PEG) contained in mRNA-based vaccine formulations

It is known that some PEGylated drugs and products for human use which contain PEG are capable of eliciting immune responses that lead to to detectable PEG-specific antibodies in serum. In this study, we determined if any of the components of mRNA-1273 or BNT162b2 formulations elicited PEG-specific antibody responses in serum by enzyme linked immunosorbent assay (ELISA)

已知部分含聚乙二醇（Polyethylene Glycol，PEG）的人用聚乙二醇化药物及制品，可诱发免疫应答，进而在血清中产生可检测到的抗PEG特异性抗体。本研究采用酶联免疫吸附试验（Enzyme Linked Immunosorbent Assay，ELISA），旨在明确mRNA-1273与BNT162b2疫苗制剂的任一组分，是否会在血清中诱发抗PEG特异性抗体应答。