Nationwide prevalence and incidence study of neuromyelitis optica spectrum disorder in Denmark

Objectives: To estimate the nationwide population-based incidence, prevalence, and geographical distribution of neuromyelitis optica spectrum disorder in Denmark based on the 2015 International Panel for NMO Diagnosis (IPND) criteria
Methods: We conducted a multicentre, historically prospective study. Data were sourced from the Danish National Patient Registry, the Danish Multiple Sclerosis Registry, departments of neurology and laboratories providing aquaporin 4 (AQP4) antibody test. Cases were selected based on the 2006 Wingerchuk and the 2015 IPND criteria and were individually validated by an expert panel.
Results: We confirmed NMO in 30 cases (2006 criteria), and NMOSD in 56 cases (2015 IPND criteria) between 2007 and 2014. Defined by the 2006 criteria, the incidence of NMO was 0.029 per 100,000 person-years (95% CI;0.014 - 0.051), and the prevalence (age ≥ 16) was 0.566 per 100,000 (95% CI;0.370 - 0.830). Based on the 2015 IPND criteria, the incidence of NMOSD was 0.070 per 100,...

研究目标：基于2015年视神经脊髓炎诊断国际小组（International Panel for NMO Diagnosis, IPND）制定的诊断标准，估算丹麦全国范围内视神经脊髓炎谱系疾病（neuromyelitis optica spectrum disorder, NMOSD）的人群发病率、患病率及地理分布。
研究方法：本研究为多中心历史性前瞻性研究，数据来源于丹麦国家患者登记库、丹麦多发性硬化登记库，以及提供水通道蛋白4（aquaporin 4, AQP4）抗体检测的神经内科科室与实验室。研究病例依据2006年Wingerchuk标准及2015年IPND标准筛选，并由专家小组对每一例病例进行独立审核验证。
研究结果：本研究确认2007至2014年间，符合2006年诊断标准的视神经脊髓炎（neuromyelitis optica, NMO）病例共30例，符合2015年IPND标准的NMOSD病例共56例。以2006年标准计算，NMO的发病率为0.029/10万人年（95%置信区间：0.014~0.051），年龄≥16岁人群的患病率为0.566/10万人（95%置信区间：0.370~0.830）。依据2015年IPND标准，NMOSD的发病率为0.070/10万人……