Astrocytoma, anaplastic, IDH-mutant - Male, 45 - Tissue image [5270730023439131]

This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 45Clinical description: Brain tumor.Gender: MaleDiagnosis:Classification: ICD-O_3.2Classification code: GLIOMASDiagnosis: Astrocytoma, anaplastic, IDH-mutantResult of the histopathological examination: Diffuse anaplastic astrocytoma (G3), IDH1 - mutated.

IHC: IDH1R132+, p53 - overexpressed, ATRX +/-, Ki67 up to 5%, CDKN2A+ .Sample:Material: FFPECollecting method: Surgical specimenTopography: EYE, BRAIN AND OTHER PARTS OF CENTRAL NERVOUS SYSTEMOrgan: BRAINTissue: Parietal lobeType of staining: positive/IHCStaining: Not applicableAntibody: p16Technology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk

本数据集为格但斯克医科大学（Medical University Gdańsk）获取并存入ZMDL-GUMED数据库的脑组织样本组织病理学图像。该样本图像采用Pannoramic 250 3DHistech切片扫描仪采集，放大倍率为20倍，最终以数字成像与通信医学（Digital Imaging and Communications in Medicine, DICOM）格式存储。

患者、样本及诊断详细信息如下：
患者信息：年龄45岁，临床表征为脑肿瘤，性别为男性。
诊断分类：依据ICD-O_3.2分类标准，分类编码为GLIOMAS（神经胶质瘤），具体诊断为IDH突变型间变性星形细胞瘤。
组织病理学检查结果：弥漫性间变性星形细胞瘤（G3级），IDH1基因突变。
免疫组化（Immunohistochemistry, IHC）检测结果：IDH1R132阳性、p53过表达、ATRX表达不定（±）、Ki67增殖指数最高达5%、CDKN2A阳性。
样本相关信息：
- 样本材质：福尔马林固定石蜡包埋（Formalin-Fixed Paraffin-Embedded, FFPE）组织
- 采集方式：手术标本
- 解剖部位：眼、脑及中枢神经系统其他部分
- 所属器官：脑
- 组织来源：顶叶
- 染色类型：免疫组化阳性染色
- 具体染色方案未明确，所用抗体为p16
技术参数：
- 扫描设备：Pannoramic 250 3DHistech
- 物镜倍率：20倍
来源机构：格但斯克医科大学