Number of anticoagulation-naive patients with NVAF who at the moment of inclusion in the START-Register would have been compliant with the lower limit of creatinine clearance declared by the drug companies and with the criteria established from the Italian Regulatory Agency (AIFA), in order to be potentially treated with DOA.

CrCl = creatinine clearance
*after exclusion of 168 patients with CrCl< 30 ml/min
**after exclusion of 14 patients with CrCl< 15 ml/min
¶after exclusion of 14 patients with CrCl< 15 ml/min
The criterion regarding the individual difficulties in performing the laboratory control of INR, as well as the percentage of time in range (all the START-Register patients were VKA-naive at inclusion) have not been taken into account for this evaluation.