Effects of probiotics on the lipid profile: systematic review

Abstract Alterations in the intestinal microbiota can modulate mechanisms involving risk factors for cardiovascular diseases, including dyslipidemias The objective was to review the effects of probiotic supplementation on the prevention and treatment of changes to the lipid profile. The searches were run on the PubMed database, using the descriptors “probiotics and lipid profile” and “probiotics and dyslipidemia,” with publication dates restricted to 2013 to 2018. Supplementation with probiotics significantly reduced total cholesterol, LDL-c, and triglycerides and increased HDL-c. Some benefits were observed on anthropometric variables, glycemic control, oxidative stress, inflammation, and immune system. The present study suggests that probiotic supplementation should be indicated as adjunctive treatment for dyslipidemias. Further studies should be developed to clarify long-term effects, as well as the influence of probiotics in combination with drug therapy.

摘要 肠道菌群的改变可调控涉及心血管疾病危险因素的多种机制，其中包括血脂异常（dyslipidemia）。本研究旨在综述益生菌（probiotics）补充剂对血脂谱（lipid profile）异常的预防与治疗作用。本研究基于PubMed数据库开展检索，采用的主题检索词为“益生菌与血脂谱”及“益生菌与血脂异常”，检索时限限定为2013年至2018年。研究结果显示，益生菌补充剂可显著降低总胆固醇、低密度脂蛋白胆固醇（LDL-c）、甘油三酯水平，并升高高密度脂蛋白胆固醇（HDL-c）水平。此外，在人体测量学变量、血糖控制、氧化应激、炎症反应及免疫系统功能方面均观察到部分获益。本研究提示，益生菌补充剂可作为血脂异常的辅助治疗手段。未来应开展更多研究以阐明其长期效应，以及益生菌与药物联合治疗的相关影响。