Differential host signaling pathway modulation in Ebola-infected cells 1 h post-infection.

Differential host signaling pathway modulation identified by pathway ORA through the direct comparison of mock-infected and EBOV-infected macrophages 1 hr post-infection. The online software InnateDB was utilized for pathway over-representation analysis. Based on levels of differential expression InnateDB is able to predict pathways that are consistent with the experimental data. Pathways are assigned a probability value (p) based on the number of proteins present for a particular pathway. It also provides the number of uploaded pathways associated with a particular pathway as well as the subset of individual genes that are differentially expressed.