Activity of human neural crest enhancer near COL13A1 in E11.5 transgenic mouse embryo - Tg(hg38_chr10:69710540-69711365::LacZ).

Tg(hg38_chr10:69710540-69711365::LacZ) human neural crest enhancer with biased activity in the frontonasal process, periocular mesenchyme/optic cup, maxillary and mandibular 1st branchial arch, 2nd branchial arch, 3rd branchial arch, heart field, forelimb and hindlimb buds, and somites in comparison to the activity of the equivalent chimp enhancer. LacZ signal was also consistently observed in the forebrain, midbrain, hindbrain, trigeminal (V) ganglion, and midgut.

携带hg38版本人类10号染色体69710540-69711365区域序列并融合LacZ报告基因的转基因（Tg）构建体所搭载的人类神经嵴增强子（enhancer），与同源黑猩猩增强子的活性相比，在额鼻突、眼周间充质/视杯、上颌突与下颌突组成的第一鳃弓、第二鳃弓、第三鳃弓、心区、前肢芽、后肢芽以及体节中呈现出偏好性表达活性。此外，在前脑、中脑、后脑、三叉神经（V）节以及中肠中也可稳定检测到LacZ信号。