Sterol regulatory element-binding proteins (SREBP) signaling

Sterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcriptional level to maintain cellular lipid homeostasis. In addition, SREBP appears to be involved in a variety of other cellular processes. This pathway of SREBP focuses on the regulation of lipid metabolism by SREBP. The data on which this pathway is based, is derived from a variety of in vitro and in vivo studies using different species, including mouse, rat, hamster and human. This pathway served as the basis for a review about SREBP that was published in Genes and Nutrition: [http://www.ncbi.nlm.nih.gov/pubmed/23516131 PubMed]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1982 CPTAC Assay Portal].

固醇调节元件结合蛋白（SREBPs）是一种膜结合蛋白，充当转录因子。它们在转录水平上调控脂质，尤其是胆固醇的生物合成和摄取，以维持细胞脂质稳态。此外，SREBP似乎还参与多种其他细胞过程。本通路专注于SREBP对脂质代谢的调控。基于此通路的数据来源于多种体外及体内研究，涉及不同物种，包括小鼠、大鼠、仓鼠和人类。该通路是发表在《基因与营养》杂志上的关于SREBP综述的基础：[http://www.ncbi.nlm.nih.gov/pubmed/23516131 PubMed]。该通路上的蛋白质可通过[https://assays.cancer.gov/available_assays?wp_id=WP1982 CPTAC 测定门户]进行靶向测定。