Identifying colorectal cancer-specific vulnerabilities in the Wnt-driven long-noncoding transcriptome [GRO-seq]
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE206582
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资源简介：
Aberrant Wnt pathway activation is the key driver of colorectal cancer (CRC) development and essential to sustain tumour growth and progression. Although the downstream protein-coding target genes of the Wnt cascade have been well-defined, the long non-coding transcriptome (lncRNAs) has not been resolved in similar detail. We here use global run-on sequencing (GROseq) to define a set of non-coding transcripts that are regulated by the β-catenin/TCF transcriptional complex in CRC. Use of global run-on sequencing (GROseq) to define a set of non-coding transcripts that are regulated by the β-catenin/TCF transcriptional complex in CRC **Please note that the records are incomplete as the submitter was unable to provide the correctly-formatted raw data files for the GSM6257143-GSM6257170 samples***
创建时间：
2025-04-30
