Master_Summary.xlsx

This dataset consists of scanning electron microscopy (SEM) measurements and sequencing data of two population specific variants; rs11150606 (chr16:g.31087690T>C (hg38) p.Gln30Arg) observed in East Asian (EAS) and Native and Latin Americans and rs201075024 (chr16:g.31087679C>T (hg38 p.Gly34Ser) which is observed exclusively in South Asians (SAS) in PRSS53. These variants are thought to influence hair shape. The samples were subsequently sequenced for the EDAR variant rs3827760 (chr2:g.108897145G>C (hg38p.Val370Ala).Malaysians (sample size: 99) from different ethnicities were recruited for this study and hair and saliva samples were collected from all the participants, after obtaining informed consent. DNA extracted from saliva samples was genotyped by sequencing a fragment of the PRSS53 gene and EDAR gene. The samples then underwent hair phenotype assessment using a scanning electron microscope (SEM). The images captured were measured for several parameters using ImageJ, and the measurements were tabulated. The SEM images and sequencing files are available with this data set. Mouse hair samples were obtained from University of Edinburgh and Sanger Institute. These samples consist of a knockout, SAS specific variant and EAS specific variant strains, for the PRSS53 variants. Auchene hair samples were used for the SEM analysis, where the images were analysed with ImageJ, and the data tabulated.

本数据集包含两种特定人群变异的扫描电子显微镜（SEM）测量和测序数据；分别为东亚人群（EAS）及土著和拉丁美洲人群中的rs11150606（chr16:g.31087690T>C (hg38) p.Gln30Arg）和仅在印度次大陆人群（SAS）中发现的rs201075024（chr16:g.31087679C>T (hg38 p.Gly34Ser)），这些变异被认为会影响发形。随后，对EDAR变异rs3827760（chr2:g.108897145G>C (hg38p.Val370Ala)）的样本进行了测序。为此研究招募了不同族裔的马来西亚人（样本量：99人），并从所有参与者处收集了头发和唾液样本，在获得知情同意后进行。从唾液样本中提取的DNA通过测序PRSS53基因和EDAR基因的片段进行基因分型。随后，使用扫描电子显微镜（SEM）对样本进行毛发表型评估，并通过ImageJ测量捕获的图像的多个参数，并将测量结果进行表格化。SEM图像和测序文件均包含在本数据集中。来自爱丁堡大学和Sanger研究所的鼠类毛发样本被用于SEM分析，图像使用ImageJ进行分析，并将数据表格化。