Impact of Cerium Oxide Nanoparticles on Rat Myoblast Proteome

Oxidative stress is a widespread causative agent of disease. Together with its general relevance for biomedicine, such dynamic is recognizably detrimental to space exploration. Among other solutions, cerium oxide nanoparticles (or nanoceria, NC) display a long-lasting, self-renewable antioxidant activity. In a previous experiment, we evaluated oxidative imbalance in rat myoblasts in space – aboard the International Space Station –, and unveiled possible protective effects from NC through RNA sequencing. Here we focus on myoblast response to NC on land by means of proteomics, defining a list of proteins that putatively react to NC and confirming nucleosomes/histones as likely mediators of its molecular action.