Opposing effects of plasma LDL on white matter integrity in older APOE4 carriers

Supplementary Table 1. List of brain Injury, neurologic disorders, and mental illness conditions included in our sample exclusion criteria.Supplementary Table 2. A list of 249 nuclear magnetic resonance (NMR) metabolic biomarkers.Supplementary Table 3. A list of 39 regional white matter (WM) integrity measured by fractional anisotropy (FA).Supplementary Table 4. The p-values of linear regression analyses by regressing each covariate on each white matter (WM) integrity tract measured by fractional anisotropy (FA). Supplementary Table 5. The false discovery rate adjusted p-values of linear regression analyses between APOE4 genotype and each white matter (WM) integrity tract measured by fractional anisotropy (FA). Supplementary Table 6. The false discovery rate adjusted p-values of linear regression analyses between each metabolite and each white matter (WM) tract measured by fractional anisotropy (FA). Supplementary Table 7. Quality control summary of cognitive data. Supplementary Table 8. Schmid Leiman factor loadings for the cognitive g factor derived from factor snalysis.

补充表1. 本研究样本排除标准所涵盖的脑损伤、神经系统疾病及精神疾病条目列表。
补充表2. 249项核磁共振（nuclear magnetic resonance, NMR）代谢生物标志物列表。
补充表3. 39项通过各向异性分数（fractional anisotropy, FA）测定的脑区白质（white matter, WM）完整性指标列表。
补充表4. 将各协变量对每项通过各向异性分数（fractional anisotropy, FA）测定的白质（white matter, WM）完整性纤维束进行回归的线性回归分析P值。
补充表5. APOE4基因型与每项通过各向异性分数（fractional anisotropy, FA）测定的白质（white matter, WM）完整性纤维束之间线性回归分析的错误发现率校正P值。
补充表6. 各代谢物与每项通过各向异性分数（fractional anisotropy, FA）测定的白质（white matter, WM）纤维束之间线性回归分析的错误发现率校正P值。
补充表7. 认知数据质量控制汇总。
补充表8. 基于因子分析推导的认知g因子的施密德-莱曼（Schmid Leiman）因子负荷量。