Severity of hot flushes is inversely associated with dietary intake of vitamin B<sub>6</sub> and oily fish
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<b>Objectives:</b> This study investigated the links between the severity of vasomotor symptoms (VMS) and the dietary consumption of a variety of nutrients. <b>Method:</b> A cross-sectional analysis of the first-visit records of 262 women aged 40–65 years was conducted. The severity of their hot flushes (HF) and night sweats (NS) and their dietary consumption of nutrients were evaluated using the Menopausal Health-Related Quality of Life Questionnaire and the brief-type self-administered Diet History Questionnaire, respectively. The relationships between severity of HF/NS and dietary intake were analyzed separately for 43 major nutrients. We then evaluated different food items as sources of the nutrients. <b>Results:</b> After adjustment for age, body mass index, menopausal status, and background factors significantly related to VMS, only vitamin B<sub>6</sub> (VB<sub>6</sub>) was significantly related to severity of HF (adjusted odds ratio per 10 μg/MJ in VB<sub>6</sub> intake, 0.92; 95% confidence interval, 0.86–0.97). Moreover, a significant inverse relationship was found between the consumption of oily fish as a source of VB<sub>6</sub> and the severity of HF. <b>Conclusions:</b> VB<sub>6</sub> and oily fish intake is inversely associated with the severity of HF in middle-aged women. Therefore, increased intake of VB<sub>6</sub> could help attenuate HF.
<b>研究目的：</b> 本研究探讨了血管舒缩症状（vasomotor symptoms, VMS）严重程度与多种营养素膳食摄入之间的关联。 <b>研究方法：</b> 本研究对262名年龄介于40至65岁的女性首次就诊记录开展横断面分析。分别采用绝经相关健康生活质量问卷（Menopausal Health-Related Quality of Life Questionnaire）与简易自评饮食史问卷（brief-type self-administered Diet History Questionnaire），评估受试者的潮热（hot flushes, HF）与夜间盗汗（night sweats, NS）严重程度，以及营养素膳食摄入情况。针对43种主要营养素，分别分析潮热/夜间盗汗严重程度与膳食摄入量之间的关联；随后进一步探究作为营养素来源的各类食物。 <b>研究结果：</b> 在对年龄、体重指数（body mass index, BMI）、绝经状态以及与血管舒缩症状显著相关的背景因素进行校正后，仅维生素B₆（vitamin B₆, VB₆）与潮热严重程度存在显著关联（维生素B₆摄入量每增加10 μg/MJ，校正后比值比为0.92；95%置信区间为0.86~0.97）。此外，作为维生素B₆来源的油性鱼类摄入量与潮热严重程度呈显著负相关。 <b>研究结论：</b> 中年女性的维生素B₆与油性鱼类摄入量与潮热严重程度呈负相关。因此，增加维生素B₆的摄入或可缓解潮热症状。
