Project PrEPare - An Open Label Demonstration Project and Phase II Safety Study of Pre-exposure Prophylaxis Use Among Young Men Who Have Sex With Men (YMSM) in the United States

A pre-exposure prophylaxis (PrEP) demonstration project and Phase II safety study to obtain additional data on the safety of emtricitabine/tenofovir (FTC/TDF (Truvada�)) and evaluate patterns of use, rates of adherence, and patterns of sexual risk behavior among YMSM (inclusive of transgender women) who were provided with open label FTC/TDF and information on the safety and efficacy of PrEP from prior studies. This project also explored the feasibility and acceptability of implementing two different efficacious risk reduction interventions prior to provision of PrEP - Many Men, Many Voices (3MV) and Personalized Cognitive Counseling (PCC).

本研究为一项暴露前预防（PrEP）示范项目与II期安全性研究，旨在获取恩曲他滨/替诺福韦（FTC/TDF（特鲁瓦达®））的安全性补充数据，并评估接受开放标签恩曲他滨/替诺福韦、且获取了既往研究中PrEP安全性与有效性相关信息的青年男男性行为者（YMSM，含跨性别女性）的用药模式、服药依从率及性风险行为特征。本项目同时探索了在提供PrEP前实施两种不同高效风险降低干预措施的可行性与接受度——即众男众声（3MV）项目与个性化认知咨询（PCC）。