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Extensive changes in DNA methylation are associated with expression of mutant huntingtin

ChEBI2013-01-22 更新2026-07-21 收录

亨廷顿病分子机制

表观遗传学DNA甲基化

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-43433 数据链接链接失效反馈

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Extensive changes in DNA methylation are associated with expression of mutant huntingtin

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创建时间：

2013-01-22

亨廷顿病分子机制

表观遗传调控

Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain.

NIAID Data Ecosystem30

Investigating huntingtin-DNA binding by EMSA and DSLS (2017/05/31)

亨廷顿病分子机制

蛋白质结构与功能研究

Huntingtin structure-function open lab notebook project

NIAID Data Ecosystem10

Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity

亨廷顿病分子机制

免疫疗法开发

We have generated eight mAbs (MW1–8) that bind the epitopes polyglutamine (polyQ), polyproline (polyP), or the C terminus of exon 1 in huntingtin (htt) protein. In the brains of Huntington's disease (

PubMed Central2002-01-15 更新10

mRNA-Seq Expression profiling of human post-mortem BA9 brain tissue for Huntington's Disease and neurologically normal individuals

亨廷顿病分子机制

组织基因表达

Huntington’s Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD

NIAID Data Ecosystem20

ER_RNASeq_LAQ5MGvsCONTROL.xlsx

亨廷顿病分子机制

RNA测序分析

The RNASeq Raw data related to the article of "Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease" Figure 4

NIAID Data Ecosystem10

Extensive changes in DNA methylation are associated with expression of mutant huntingtin

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