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Crystal Structure of Acetyl-CoA synthetase in complex with a cyclopropyl ester AMP inhibitor from Cryptococcus neoformans H99

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Protein Data Bank Japan2025-10-29 更新2026-04-19 收录
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Crystal Structure of Acetyl-CoA synthetase in complex with a cyclopropyl ester AMP inhibitor from Cryptococcus neoformans H99 Descriptor: 1,2-ETHANEDIOL, 5'-O-[(R)-(cyclopropyloxy)(hydroxy)phosphoryl]adenosine, Acetyl-coenzyme A synthetase Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-02-01 Release date: 2023-02-15 Last modified: 2025-10-29 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Discovery and mechanism of a highly selective, antifungal acetyl-CoA synthetase inhibitor. Nat Commun, 16, 2025
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2023-02-01
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