MCPIP1 controls effects of myeloid cells on skin carcinogenesis and hair growth

Depletion of Mcpip1 in the cells of myeloid origin modifies the sensitivity to the cutaneous chemical carcinogenesis. It attenuates epidermal proliferation and increases the susceptibility to the formation of melanocytic nevi. Thus, myeloid Mcpip1 is an important modulator in the course of skin carcinogenesis. Overall design: RNA-seq was performed to analyse transcriptome of chemically induced skin lesions and adjacent skin from four control and four Mcpip1(MKO) (myeloid-specific knockout) mice.