TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.
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https://www.omicsdi.org/dataset/pride/PXD019087
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资源简介：
The PIWI protein MIWI2 and its associated PIWI-interacting RNAs (piRNAs) instruct DNA methylation of young active transposable elements (TEs) in the male germline. Here we show that MIWI2 associates with TEX15 in foetal gonocytes. TEX15 is predominantly a nuclear protein that is not required for piRNA biogenesis but is essential for piRNA-directed TE de novo methylation and silencing. In summary, TEX15 is an essential executor of mammalian piRNA-directed DNA methylation.
创建时间：
2020-06-18
