Targeted Metabolomics in the REGARDS Stroke Case-Cohort Study

Targeted Metabolomics in the REGARDS Stroke Case-Cohort Study.
A prospective epidemiological study with a case-cohort design.
Targeted metabolomics was conducted on plasma samples from a nested case-cohort study within the bi-racial REasons for Geographic and Racial Differences in Stroke (REGARDS), a longitudinal prospective cohort. The REGARDS study was designed to investigate different health outcomes with a focus on stroke disparities across the USA. Participants were oversampled from the Southeastern regions of the "stroke belt," where stroke risk and mortality are 2-4 times higher in the African American population. The study recruited 30,239 community-dwelling Black and White participants aged 45 years or older. Plasma samples were collected during the baseline study visit between 2003 and 2007 and stored at -80°C. This dataset includes a total of 2,378 plasma samples representing the stroke case-cohort sub-study. Participants of the random cohort (N=1,056) were selected at the point of enrolment. Stroke cases were adjudicated up to April 2009 (N=1,322).

REGARDS卒中病例队列研究中的靶向代谢组学。
本研究为采用病例队列设计的前瞻性流行病学研究。
针对双种族纵向前瞻性队列研究「卒中地理与种族差异原因研究（REasons for Geographic and Racial Differences in Stroke, REGARDS）」中的嵌套病例队列研究的血浆样本开展了靶向代谢组学检测。REGARDS研究旨在探究各类健康结局，重点关注美国全国范围内的卒中发病差异。研究对「卒中带」东南部地区的参与者进行了过度抽样——该区域非洲裔美国人群的卒中风险与死亡率为其他人群的2至4倍。本研究共招募30239名年龄在45岁及以上、居住于社区的黑人和白人参与者。研究于2003年至2007年的基线访视期间采集血浆样本，并将样本保存于-80℃环境中。本数据集共计包含2378份对应卒中病例队列子研究的血浆样本。随机队列（N=1056）的参与者在入组时即被选定。截至2009年4月，共经裁定确认卒中病例1322例（N=1322）。