Expression data for mouse skin-in atopy DNCB model. Expression data for mouse skin-in atopy DNCB model

Atopic dermatitis (AD) is the most common chronic inflammatory skin disorder, characterized by intense itch and recurrent eczematous lesions. Due to lack of proper therapy, the strategies of T cell modulators in combination with targeting keratinocytes and/or myeloid cells might hold promise for achieving disease control in AD patients better than T cell modulators alone. we used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during HY209 treatment in mouse skin Overall design: DNCB was applied on the dorsal skin of Balb/c mice for 15 days and treated with vehicle or 5% HY209-PEG gel for the last 7 days. The skin samples were collected for RNA and the gene expression analysis.