Developmental air pollution exposure augments airway hyperreactivity, alters transcriptome, and DNA methylation in female adult progeny

Allergic airways disease model used to show developmental exposure to pm2.5 air pollution particulates causes worsened airway hyperreactivity in offspring, and associated changes in lung transcriptome and DNAm.

该变应性气道疾病模型用于阐明发育阶段暴露于PM2.5空气颗粒物会使子代气道高反应性加剧，并伴随肺转录组与DNA甲基化（DNAm）的相关变化。