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Myeloproliferative Neoplasm-Blast Phase Stem Cells Originate from the Hematopoietic Stem Cell Compartment and Display Clonal and Functional Heterogeneity

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NIAID Data Ecosystem2026-03-13 收录
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Chronic myeloproliferative neoplasms (MPN) frequently evolve to a blast phase (BP) that is almost uniformly resistant to treatment. We explored the functional properties, genomic architecture, and cell of origin of MPN-BP using a serial NSG mouse xenograft system.

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2022-01-01
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