RELATIONSHIP BETWEEN PARVOVIRUS B19 AND OSTEOARTHRITIS: LITERATURE REVIEW

ABSTRACT Osteoarthritis and Parvovirus B19 infection present silent and gradual evolution, since the former is a degenerative process while the latter is often asymptomatic and may persist in the individual’s body during their life. This study aims to analyze clinical studies that establish a correlation between degenerative osteoarthritis and Parvovirus B19 infection. Of the 62 studies found, 25 were chosen for reading in full. Analyzing only the studies that establish the correlation between the pathologies, seven confirm this relationship between Parvovirus B19 and Osteoarthritis, while one reports no relationship. No objective correlation could be found between the other articles studied. Our findings suggest that there is a close relationship between Parvovirus B19 and Osteoarthritis, with a higher prevalence of acquired causes, women and older adults, but it can manifest during life. However, it is essential to carry out new studies involving family history of patients with Osteoarthritis with positivity of Parvovirus B19, cohort studies between childhood and adult-old adult, so that it can elucidate this duality of congenital-acquired cause and, finally, raise treatment alternatives. Level of Evidence II, Systematic Review of Level II Studies.

【摘要】骨关节炎（Osteoarthritis）与细小病毒B19（Parvovirus B19）感染均呈隐匿且渐进的病程：前者为退行性病变，后者通常无明显症状，且可在感染者体内终身持续存在。本研究旨在分析探讨退行性骨关节炎与细小病毒B19感染之间相关性的临床研究。在所检索到的62项研究中，筛选25项进行全文研读。在明确探讨两种疾病相关性的研究中，7项证实了细小病毒B19与骨关节炎之间存在关联，1项则报告无相关关系，其余纳入分析的文献未发现明确的相关性。本研究结果提示，细小病毒B19与骨关节炎之间存在密切关联，且该关联在获得性病因、女性及老年人群中患病率更高，且可在感染者一生中出现。然而，仍有必要开展新的研究，纳入伴有细小病毒B19阳性的骨关节炎患者家族史信息、开展儿童期至老年期的队列研究，以阐明其先天性-获得性病因的双重性，并最终提出可供选择的治疗方案。本研究证据等级为Ⅱ级，属于对Ⅱ级研究的系统评价。