HLA data by gender used in the model#.

#Numbers listed are genotype frequencies.2HB+ = carrier of 2 copies of the DRB1*1501 allele (homozygous carrier).1HB+ = carrier of 1 copies of the DRB1*1501 allele (heterozygous carrier).HLA− = carrier of 0 DRB1*1501 alleles;(HLA+) = (2HB+)+(1HB+).†UCSF Databases: J Oksenberg (personal communication).UCSF #1 (IMSGC) – 779 cases (76% women).UCSF #2 (GeneMSA) – 485 cases (68% women) and 431 Controls (66% women).††Hardy Weinberg Equilibrium (HWE) values predicted based on the observed P(2HB+) in Cases or Controls. Because of the small number of men in these samples, the number of males with 2 copies of HLA DRB1*1501 was tiny. Therefore, in men, HWE was estimated from the observed P(HLA−).*Odds ratio (OR) versus controls. Calculated as odds of genotype in cases divided by odds of the same genotype in controls.