Comparative quantitative mass spectrometry analysis of MHC class II-associated peptides reveals a role of GILT in formation of self-peptide repertoire.

I-Ab-specific epitopes were eluted from the splenocytes of GILT+/+ and GILT-/- mice. The authors concluded that self-proteins involved in some of the fundamental cellular processes might be processed differently in the absence of GILT and presented on the cell surface more frequently.