Klebsiella pneumoniae strain:KP217360 Genome sequencing. Klebsiella pneumoniae strain:KP217360

Klebsiella pneumoniae KP217360 exhibited resistance to most antibiotics, including imipenem, ertapenem, and ceftazidime/avibactam. It belonged to the KL16 capsular type and carried multiple resistance genes, including blaCTX-M-65, blaSHV-103, blaTEM-1, and several iron acquisition-related virulence genes such as iutA, entABCDEF, and iroN. The strain harbored three plasmids, with one being of the IncX3 type carrying the blaNDM-5 resistance gene, while the functions of the other two remained unclear. Therefore, KP217360 was identified as a carbapenem-resistant high-virulence Klebsiella pneumoniae; in the toxicity test on Galleria mellonella, it was found that the survival rate of the KP217360 group was only 40% after 72 hours, significantly lower than the 70% survival rate of the control group.