Expression data from DP cells in the thymus of SRSF1-null and wild type mice. Expression data from DP cells in the thymus of SRSF1-null and wild type mice

iNKT cells are highly conserved innate-like T lymphocytes that develop from CD4+CD8+ DP cells. It remains largely unknown whether post-transcriptional regulation has critical roles in iNKT cells. Here we show conditional deactivation of SRSF1 in DP thymocytes impaired iNKT cell development and survival in a cell-intrinsic manner. Overall design: WT and SRSF1-null CD4+CD8+ DP cells (2 samples per group) were sorted. Then the total RNAs were extracted and subjected to RNA sequencing.