Supplemental Tables A to F for "Cord blood DNA methylation reflects cord blood C-reactive protein levels..."

Results using EPIC microarray to investigate maternal CRP in the pregnancy and delivery with cord blood DNA methylation. Results from model 1 adjusting for maternal age, smoking, income, pre-pregnancy BMI, and plate. Model 2 additionally adjusts for cell type distribution using the cord blood reference as published by Bakulski et al. 2016. Model 3 adjusts for model 1 covariates and cell type distribution using the cord blood reference published by Gervin, Salas et al. 2019. Results are from first trimester (week 8), second trimester (week 20), third trimester (week 36), cord blood, cumulative (AUC) or persistent (extreme tertiles) CRP.<br>Supports the publication:<br>Yeung, E.H., Guan, W., Zeng, X. et al. Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis. Clin Epigenet 12, 60 (2020). https://doi.org/10.1186/s13148-020-00852-2<br>

本研究采用EPIC微阵列（EPIC microarray）探究妊娠及分娩过程中母体C反应蛋白（CRP, C-reactive protein）与脐带血DNA甲基化的关联。本分析使用三个模型得到结果：模型1校正了母体年龄、吸烟状况、收入水平、孕前体质量指数（BMI, body mass index）及芯片批次的影响；模型2在模型1的校正基础上，额外采用Bakulski等于2016年发表的脐带血参考数据集校正细胞类型分布；模型3则在模型1协变量的基础上，采用Gervin、Salas等于2019年发表的脐带血参考数据集校正细胞类型分布。分析结果涵盖妊娠早期（第8周）、妊娠中期（第20周）、妊娠晚期（第36周）的母体CRP水平、脐带血样本数据，以及累积（曲线下面积，AUC, area under the curve）或持续性（极端三分位数）CRP水平。
本数据集支持以下已发表学术论文：
Yeung, E.H.、Guan, W.、Zeng, X. 等. 脐带血DNA甲基化可反映脐带血C反应蛋白水平而非母体水平：一项纵向研究与荟萃分析. 临床表观遗传学（Clin Epigenet）, 12, 60 (2020). https://doi.org/10.1186/s13148-020-00852-2