Figure 3 () TUNEL-positive myocytes nuclei (brown) demonstrated with the ApopTag kit

The transverse section is from the left ventricle in a case of SND (× 200 magnifications). The insert: Higher magnification (× 400) of the same section showing complete labelling of myocytes nuclei. () Myocytic necrosis visualized by the binding of antibody against the terminal complement complex (purple) to the sarcolemma. The longitudinal is from the left ventricle in a case of LLT group (× 200 magnification).Insert: Higher magnification (× 400) of the same section showing immunoreactivity of cardiac myocytes to the C9-mab. The endothelium of intramyocardial vessels also reacted with C9-ab and used as an internal control (arrow).<b>Copyright information:</b>Taken from "Pathogenic role of cardiac mast cell activation/degranulation, TNF-α, and cell death in acute drug-related fatalities"Vascular Health and Risk Management 2007;3(6):1053-1062.Published online Jan 2007PMCID:PMC2350147.© 2007 Perskvist et al, publisher and licensee Dove Medical Press Ltd.

本横切片取自SND病例的左心室，放大倍数为200倍。插图：同一切片的高倍放大视野（400倍），可见心肌细胞核被完全标记。心肌细胞坏死可通过抗终末补体复合物抗体（呈紫色）与肌膜的结合得以显示。本纵行切片取自LLT组病例的左心室，放大倍数为200倍。插图：同一切片的高倍放大视野（400倍），可见心肌细胞对C9单克隆抗体（C9-mab）呈免疫反应性。心肌内血管的内皮细胞同样可与C9抗体结合，以此作为内部对照（箭头所示）。<b>版权信息：</b>本文摘自《急性药物相关死亡中心脏肥大细胞活化/脱颗粒、肿瘤坏死因子-α（TNF-α）及细胞死亡的致病作用》，发表于《Vascular Health and Risk Management》2007年；3(6):1053-1062，2007年1月在线发表，PMCID:PMC2350147。©2007 Perskvist等，出版方及授权方为Dove Medical Press Ltd.