Raw data for Association of ACE2 gene functional variants with gestational diabetes mellitus risk in a southern Chinese population

These data were generated to investigate the association and functional analysis of angiotensin-converting enzyme 2 genetic variants with the pathogenesis of Gestational diabetes mellitus (GDM). This study conducted a case-control study involving 569 GDM patients and 735 healthy pregnant women to explore the associations between candidate variants in the ACE2 gene variants and the pathogenesis of GDM. This study collected clinical samples and data, and used logistic regression, false positive report rate, multi factor dimension reduction, functional analysis and other analysis methods to process the research data. Potential functional ACE2 gene variants (rs2106809 A>G, rs6632677 G>C, and rs2074192 C>T) were selected and genotyped using kompetitive allele-specific PCR. The strength of the associations between the studied genetic variants and the risk of GDM were evaluated using odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Finally, ACE2 gene variants are si..., ,

本数据集旨在探究血管紧张素转换酶2（angiotensin-converting enzyme 2, ACE2）遗传变异与妊娠期糖尿病（Gestational diabetes mellitus, GDM）发病机制的关联及功能分析。本研究采用病例对照研究设计，纳入569例GDM患者与735名健康孕妇，以探讨ACE2基因候选变异与GDM发病机制之间的关联。本研究收集了临床样本与相关数据，并采用logistic回归、假阳性报告率、多因素降维、功能分析等多种分析方法对研究数据进行处理。筛选出具有潜在功能的ACE2基因变异（rs2106809 A>G、rs6632677 G>C及rs2074192 C>T），并采用竞争性等位基因特异性PCR（kompetitive allele-specific PCR, KASP）技术完成基因分型。运用比值比（odds ratios, ORs）及其对应的95%置信区间（confidence intervals, CIs）评估所研究的遗传变异与GDM发病风险的关联强度。最后，ACE2基因变异与……