Analysis of 104 breast cancer biopsies (removed prior to any treatment with tamoxifen or chemotherapeutic agents) from patients aged between 31 years and 89 years at the time of diagnosis (mean age =
Poly (ADP-ribose) glycohydrolase (PARG) is a dePARylating enzyme which promotes DNA repair by removal of poly (ADP-ribose) (PAR) from PARP1-parylated proteins. Loss or inhibition of PARG results in r
Trascriptome analysis of mcf7 cell lines were performed MCF-7 PELP1 cells expressing LXSN, WT PELP1, or cytoplasmic (cyto) PELP1 were hormone-starved in modified IMEM containing 5% DCC for 16 hours pr
High-Grade Serous Ovarian Cancer (HGSOC), the most prevalent ovarian cancer subtype, currently treated with platinum-taxol-based chemotherapy, has a dismal five-year survival rate (>30%). Emergence of
