Evoked intracranial potentials in patients with epilepsy

The parameters affecting the evoked response in the brain as a result of brain stimulation is not well understood. Yet it is widely used in research and clinical settings (e.g. responsive neurostimulation to treat intractable multifocal epilepsy in humans). In an effort to better understand the parameters that affect the response to brain stimulation, single pulse electrical stimulation was delivered to different brain regions of patients with epilepsy undergoing long term monitoring. These data were recorded off depth and surface cortical electrodes. These are the summarized trial data derived from patients. 11 patients are included in this data set. The data are organized into a MATLAB variable type table and saved in .mat form. These data were recorded, epoched, filtered, and processed as described in the submitted manuscript "A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy" by authors Bornali Kundu, Tyler S. Davis, Brian Philip, Elliot H. Smith, Amir Arain, Angela Peters, Blake Newman, Christopher R. Butson and John D. Rolston. The columns of the table consistent of the following variables: (1) patientnum - the patient ID number (2) stimlevel - the stimulation level delivered, in microvolts (3) stimchan - the number ID of the stimulation channel (4) respchan - the number ID of the response channel from which the evoked response was measured (5) isdpth - 1 = the channel was from a depth electrode, 0 = the channel was from a cortical surface electrode (6) distance - distance between the stimulation channel and response channel in Euclidian space, in mm (7) issozstim - 1= the stimulation channel was located in the clinical SOZ, boolean variable (8) issozrep - 1= the response channel was located in the clinical SOZ, boolean variable (9) posthgpwr100 - raw trial power after bandpass filtering the epoched data from 70-150Hz, calculating the Hilbert transform of the data, and then calculating the mean from 5 - 100ms as described in the methods section, data are log transformed (10) postrawmav100 - raw voltage data mean from 5-100 ms for the trial, in milivolts, data are log transformed (11) trials - trial number ID (12) regionstim - the region of the stimulation channel determined from an atlas as described in the methods (13) regionresp - the region of the response channel determined from an atlas as described in the methods (14) issoz - boolean variable, true corresponds to if the stimulation channel, response channel, or both were in the clinical SOZ (15) regionresptype - categorical description of the region of the response channel (16) regionstimtype - categorical description of the region of the stimulation channel Funding: JDR is supported by the NIH, NCATS KL2 TR002539and NINDS R21 NS113031. BK is supported in part by a NREF neurosurgical research grant.

目前学界对于脑部刺激引发大脑诱发电位的影响参数仍未完全阐明，但该类刺激已被广泛应用于科研与临床场景中，例如用于治疗人类难治性多灶性癫痫的反应性神经刺激疗法。为深入解析影响脑部刺激响应的各类参数，本研究对接受长期颅内监测的癫痫患者的不同脑区施加单脉冲电刺激。相关数据通过深部皮层与表面皮层电极采集记录，本数据集为来自患者的汇总试验数据，共纳入11名受试者。
本数据集以MATLAB变量表的形式组织，并保存为.mat格式。所有数据均按照已投稿论文《系统性探究癫痫患者颅内诱发电位的影响参数》（作者为Bornali Kundu、Tyler S. Davis、Brian Philip、Elliot H. Smith、Amir Arain、Angela Peters、Blake Newman、Christopher R. Butson与John D. Rolston）中描述的流程完成采集、分段、滤波与预处理。
该数据表包含以下变量：
1. patientnum：患者编号ID
2. stimlevel：刺激强度，单位为微伏
3. stimchan：刺激通道编号ID
4. respchan：用于采集诱发电位的响应通道编号ID
5. isdpth：电极类型标识，1代表该通道来自深部电极，0代表来自皮层表面电极
6. distance：刺激通道与响应通道间的欧几里得空间距离，单位为毫米
7. issozstim：布尔变量，1代表刺激通道位于临床致痫灶（Seizure Onset Zone, SOZ）
8. issozrep：布尔变量，1代表响应通道位于临床致痫灶（Seizure Onset Zone, SOZ）
9. posthgpwr100：对分段后的数据进行70-150Hz带通滤波、计算其希尔伯特变换（Hilbert transform）后，提取5-100ms时段的均值得到的原始试次功率，数据已完成对数转换
10. postrawmav100：试次在5-100ms时段的原始电压均值，单位为毫伏，数据已完成对数转换
11. trials：试次编号ID
12. regionstim：通过脑图谱确定的刺激通道所属脑区（详见论文方法部分）
13. regionresp：通过脑图谱确定的响应通道所属脑区（详见论文方法部分）
14. issoz：布尔变量，当刺激通道、响应通道任意其一或两者均位于临床致痫灶时取值为真
15. regionresptype：响应通道所属脑区的分类描述
16. regionstimtype：刺激通道所属脑区的分类描述
资助信息：JDR受美国国立卫生研究院（NIH）、NCATS KL2 TR002539以及NINDS R21 NS113031项目资助。BK部分受NREF神经外科研究基金资助。