Summary of population PK-PD parameters for Cp(S), NPT and INR.
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aMean of 1,000 bootstrap analyses for PK and PD-2 estimates and mean of 100 bootstrap analyses for PD-1 estimates.bThe 2.5th and 97.5th values of the ranked bootstrap parameter estimates.cCL(S) mL/h = 240×0.543CYP2C9*3×(BSAindividual/1.74)2.14, where CYP2C9*3 = 0 in patients with CYP2C9*1/*1 and CYP2C9*3 = 1 in patients with CYP2C9*1/*3. BSAmedian is 1.74 m2.dIC50 µg/mL = 0.0725×2.07VKORC1*2×1.30CYP4F2*3, where VKORC1*2 = 0 in patients with VKORC1*2/*2, VKORC1*2 = 1 in patients with VKORC1*1/*2, CYP4F2*3 = 0 in patients with CYP4F2*1/*1 and CYP4F2*3 = 1 in patients with CYP4F2*1/*3 or CYP4F2*3/*3.eλ = 3.48×exp{0.00588×(NPT0individual–119)}, where NPT0median is 119 µg/mL.
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2015-12-02
