Structural Biology of Macromolecules and Macromolecular complexes from India

Structural biology research groups located in India constitute the INDIA-BAG and will utilize MX, SAXS and CryoEM to study different biological macromolecules. Together, these groups address multiple pathways in animals, plants, bacteria and fungi. These studies will provide fundamental mechanistic insight regarding different processes critical for the survival and propagation of the relevant organism. Many groups in the BAG study proteins from pathogens to identify novel intervention points that can be the targeted with small molecule inhibitors to inhibit the growth of the corresponding infectious agents. There are more than 50 groups that are part of this BAG and the allocated beamtime will be available for over 500 young researchers. A brief description of all the research groups is provided in the global summary and a summary of the research contributions involving data collected at ESRF is provided in the last BAG report.

位于印度的结构生物学研究团队组建了印度结构生物学束线分配联盟（INDIA-BAG），将采用X射线晶体衍射（MX）、小角X射线散射（SAXS）及冷冻电子显微镜（CryoEM）技术研究各类生物大分子。这些团队将共同阐释动物、植物、细菌及真菌中的多条生物学通路。此类研究将为理解相关生物体存活与繁殖所需的各类关键生命过程提供基础性的机制层面认知。该联盟中的多个团队以病原体来源的蛋白质为研究对象，旨在发掘全新的干预靶点，可通过小分子抑制剂对其进行靶向作用以抑制相应传染性病原体的增殖。该联盟现有超过50个研究团队，其所分配的同步辐射束线机时将面向500余名青年研究人员开放。所有研究团队的简要介绍可查阅全局总结报告，而涉及欧洲同步辐射光源（ESRF）采集数据的研究成果总结则收录于上一期BAG报告中。