Supplementary Material for: Presenting Neuropsychological Testing Profile of Autopsy-Confirmed Frontotemporal Lobar Degeneration

<b><i>Aims:</i></b> We aimed to investigate how neuropsychological test measures at presentation might differentiate frontotemporal lobar degeneration (FTLD) from Alzheimer's disease (AD). <b><i>Methods:</i></b> We compared autopsy-confirmed FTLD and definite AD with Clinical Dementia Rating ≤1. Factor scores and t values of each neuropsychological test measure were compared between FTLD and AD patients. Logistic regression analyses were applied to identify independent predictors within test measures for the differentiation of FTLD from AD. <b><i>Results:</i></b> Factor analyses showed that the memory domain was more severely impaired in AD than in FTLD, whereas the language and attention domains were more severely impaired in FTLD than in AD. Multiple logistic regression analysis showed that Letter Fluency, Boston Naming Test and delayed memory recall remained independent predictors of FTLD compared to AD. However, test measures did not discriminate between FTLD-tau and FTLD-ubiquitin.<b><i> Conclusion:</i></b> We confirm that memory and language function tests discriminate between FTLD and AD.

**<i>研究目的：</i>** 本研究旨在探讨就诊时的神经心理学测试指标能否区分额颞叶变性（frontotemporal lobar degeneration, FTLD）与阿尔茨海默病（Alzheimer's disease, AD）。**<i>研究方法：</i>** 本研究纳入经尸检确认的额颞叶变性患者与确诊阿尔茨海默病患者，且所有受试者的临床痴呆分级（Clinical Dementia Rating, CDR）均≤1。分别比较两组患者各项神经心理学测试指标的因子得分与t值，并采用逻辑回归分析，从测试指标中筛选出用于区分额颞叶变性与阿尔茨海默病的独立预测因子。**<i>研究结果：</i>** 因子分析结果显示，阿尔茨海默病患者的记忆域受损程度较额颞叶变性患者更为严重，而额颞叶变性患者的语言域与注意域受损程度则更显著。多因素逻辑回归分析结果表明，相较于阿尔茨海默病患者，字母流畅性测试（Letter Fluency）、波士顿命名测验（Boston Naming Test）及延迟记忆回忆仍为区分额颞叶变性的独立预测因子。但本研究中的测试指标无法区分τ型额颞叶变性（FTLD-tau）与泛素型额颞叶变性（FTLD-ubiquitin）。**<i>研究结论：</i>** 本研究证实，记忆与语言功能测试可有效区分额颞叶变性与阿尔茨海默病。