Villin like suppresses nasopharyngeal carcinoma proliferation by downregulating MYC

The initial manifestations of nasopharyngeal carcinoma (NPC) are subtle and imperceptible, leading to unfavorable clinical outcomes and limited therapeutic alternatives among Southeast Asian populations. In this study, we examined the potential effects of VILL on nasopharyngeal carcinoma cells. We investigated the mRNA expression levels of VILL in HONE1 EBV cells overexpressing VILL compared to control cells. Data were analyzed to identify differential gene expression between VILL-transfected and non-transfected HONE1 EBV cells. Overall design: We analyzed the transcriptome expression profiles (RNA-seq) in the nasopharyngeal carcinoma cell line HONE1-EBV upon overexpression of VILL.