Additional file 2 of Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures

Additional file 2: Supplemental Table S6. KEGG enrichment of variant genes that can be linked to genome instability. Supplemental Table S7. Statistically significant Biological Process GO terms of variant genes. Supplemental Table S8. Statistically significant Molecular Function GO terms of variant genes. Supplemental Table S9. Statistically significant Cellular Component GO terms of variant genes. Supplemental Table S10. Complete list of microsatelites found in the Chinese hamster genome. Supplemental Table S11. Microsatellites containing insertion and or deletion mutations. Supplemental Table S12. Indel loci with higher mutation frequencies in 30 mM ammonia-stressed cultures. Supplemental Table S13. Indel loci from table S12 where mutation frequency is higher in the 10 mM samples compared to the control. Supplemental Table S14. The intersection of dose-dependent indels (Table S13) and genome-wide microsatellites (S10). Supplemental Table S15. The 124 candidate microsatelite loci that exhibited dose-dependent variation in response to ammonia stress.

附加文件2：
补充表S6：与基因组不稳定性相关的变异基因的京都基因与基因组百科全书（Kyoto Encyclopedia of Genes and Genomes，KEGG）富集分析结果。
补充表S7：变异基因的统计学显著生物学过程基因本体（Gene Ontology，GO）术语。
补充表S8：变异基因的统计学显著分子功能GO术语。
补充表S9：变异基因的统计学显著细胞组分GO术语。
补充表S10：中国仓鼠基因组中鉴定得到的全部微卫星（microsatellite）序列清单。
补充表S11：携带插入或缺失突变的微卫星序列。
补充表S12：30 mM氨胁迫处理培养物中突变频率更高的插入缺失位点。
补充表S13：源自表S12的插入缺失位点，其10 mM浓度组样本的突变频率高于对照组。
补充表S14：剂量依赖性插入缺失位点（表S13）与全基因组微卫星（表S10）的交集集合。
补充表S15：124个在氨胁迫响应中呈现剂量依赖性变异的候选微卫星位点。