Epigenetic alterations associated with early prenatal dexamethasone treatment: Supplementary Figure 1 & 2

Supplementary Table 1: Location of differentially methylated CpG sites. Probe locations in relation to the nearest gene or genes (left), as well as their location in relation to the nearest CpG island (right). Frequencies are shown for three levels of analysis; probes where puncorrected &lt;0.01 (A and D), probes with and puncorrected &lt;0.01 and a group difference in methylation of 5% (B and E), probes with puncorrected &lt;0.01 and a group difference in methylation of 10% (C and F).<br><br>Supplementary Table 2: Supplementary Figure 2. Enrichment results from the GAT analysis. Enrichment results of DMPs with SNPs from the GAT analysis over four genomic bins (1, 2, 5 and 10-kb) for DEX-associated DMPs (A) and DEX x sex-associated DMPs (B). Abbreviations: IBD, inflammatory bowel disease; MDD, major depressive disorder; ARMD, age-related macular degeneration; MPV, mean platelet volume; ISB, iron status biomarkers.<br><br>

补充表1：差异甲基化CpG位点（differentially methylated CpG sites）的定位信息。左侧展示探针与最近单个或多个基因的位置关系，右侧展示探针与最近CpG岛（CpG island）的位置关系。本次统计按三类分析筛选层级给出探针频率：未校正P值（puncorrected）<0.01的探针（A、D组）、未校正P值<0.01且甲基化组间差异达5%的探针（B、E组），以及未校正P值<0.01且甲基化组间差异达10%的探针（C、F组）。<br><br>补充表2：对应补充图2的GAT分析（GAT analysis）富集结果。该结果为GAT分析中携带单核苷酸多态性（SNPs, single nucleotide polymorphisms）的差异甲基化位点（DMPs, differentially methylated positions），在4个基因组区间（1、2、5、10kb）的富集情况，分别针对与地塞米松（DEX）相关的差异甲基化位点（A组）以及DEX与性别交互作用相关的差异甲基化位点（B组）。缩写说明：IBD（inflammatory bowel disease，炎症性肠病）、MDD（major depressive disorder，重度抑郁症）、ARMD（age-related macular degeneration，年龄相关性黄斑变性）、MPV（mean platelet volume，平均血小板体积）、ISB（iron status biomarkers，铁状态生物标志物）。