Phytochemical Analysis, Multi-Element Composition and Biological Activities of Extracts and Lupenone from Albizia inundata (Mart.) Barneby & J.W.Grimes

In this study, antimicrobial activity of extracts and lupenone from A. inundata (Fabaceae, Mimosoideae), were tested. In addition, the multi-element composition of the leaves, bark and stems (heartwood) of A. inundata was evaluated using inductively coupled plasma optical emission spectrometry (ICP OES). Lupenone was isolated in the petroleum ether extract of leaves, for the first time. Biological assays were conducted to evaluate the antimicrobial (antibacterial, antifungal and antiparasitic) of extracts, their fractions and lupenone. The results showed antimicrobial and antileishmanial activity of these compounds, which may be useful for obtaining a chemical composition and biological activity database on Albizia species. For multi-element composition, we found the mean concentrations (minimum-maximum) of Al, Ca, Cr, Cu, Fe, K, Mg, Mn, Ni, P, V and Zn in the samples ranged between 0.06 and 265.41 µg g-1. Concentration ranges of Cu, Fe, Mn and Zn are large, which makes these samples as additional sources of these macronutrients.

本研究针对水淹合欢（A. inundata，豆科（Fabaceae），含羞草亚科（Mimosoideae））提取物及羽扇豆酮的抗菌活性展开了测试。此外，本研究采用电感耦合等离子体光发射光谱法（inductively coupled plasma optical emission spectrometry, ICP OES），对A. inundata的叶片、树皮及茎干（心材）的多元素组成进行了评估。本研究首次从其叶片的石油醚提取物中分离得到羽扇豆酮。通过生物学活性实验，评估了各提取物、馏分及羽扇豆酮的抗菌（含抗细菌、抗真菌及抗寄生虫）活性。结果显示，上述化合物兼具抗菌与抗利什曼原虫活性，该成果可为构建合欢属（Albizia）物种的化学成分与生物活性数据库提供支撑。在多元素组成方面，本研究测得样品中铝（Al）、钙（Ca）、铬（Cr）、铜（Cu）、铁（Fe）、钾（K）、镁（Mg）、锰（Mn）、镍（Ni）、磷（P）、钒（V）及锌（Zn）的平均浓度（最小值-最大值）区间为0.06~265.41 µg·g⁻¹。其中铜、铁、锰及锌的浓度跨度较大，表明该样品可作为上述大量营养素的额外来源。