MiRNA expression data of distal colon mucosa from young and old mice. MiRNA expression data of distal colon mucosa from young and old mice

The disruption of the mucosal barrier of the digestive tract is a common pathological change in the elderly, which often causes inflammatory bowel disease among old people.Given that microRNA (miRNA) molecules are dysregulated in many diseases, the miRNA expression in young and old normal distal colon mucosa in mice was determined by high-throughput analysis. Three 2-month-old mice and 3 24-month-old were enrolled in this study. We used sequencing analysis to identify miRNA expression in the distal colon mucosa. Overall design: Male C57BL/6 mice divided into two groups according to age, i.e., 2 and 24 month old groups (n =3 per group). All mice were housed in a controlled environment under a 12 h light/dark cycle at 22 ± 2 ℃, 55 ± 5% humidity with access to food and water ad libitum and were sacrificed by appropriate anesthesia and/or cervical dislocation prior to the sample collection. The distal colon tissues were surgically and aseptically removed from the mice. After collection, the samples were stored at -80 °C.