Interaction of integrin alphaDbeta2 with fibrin

Integrin alphaDbeta2 is a member of the beta2 family. It is expressed poorly on peripheral blood leukocytes but strongly on macrophages. alphaDbeta2 has the ability to interact with multiple ligands, including many ECM proteins. The interaction of beta2 integrins with ligands is mediated by their I-domains of the alpha subunits. The alphaD I-domain mediates the interaction with the ECM protein fibrinogen.

整合素αDbeta2属于β2家族成员。其在外周血白细胞上的表达较弱，而在巨噬细胞上的表达则强烈。αDbeta2具备与多种配体相互作用的特性，包括众多细胞外基质蛋白。β2整合素与配体的相互作用由α亚单位的I结构域介导。αD I结构域介导了与细胞外基质蛋白纤维蛋白原的相互作用。