Pogz deficiency leads to abnormal behavior, transcription dysregulation and impaired cerebellar physiology

As part of characterizing the novel pogz deficiency mouse model, we performed RNA-Seq from cerebellum and hippocampus of adult mice to discover Pogz targets and changes in gene expression that might explain the phenotypes we see in those mice Cerebellar and hippocampal mRNA profiles of control (WT), pogz+/- and pogz-/- mice, both males and females, in triplicates, using Illumina NextSeq 500为对新型pogz缺陷小鼠模型进行表型表征，我们对成年小鼠的小脑与海马体组织开展了RNA测序（RNA-Seq），以期鉴定Pogz的靶标基因并筛选可解释该模型异常表型的基因表达变化。本数据集包含使用Illumina NextSeq 500平台完成的、来自雌雄成年对照（野生型WT）、pogz+/-杂合子及pogz-/-纯合子小鼠的小脑与海马体mRNA转录组谱数据，所有组别均设置三次生物学重复。