Erratum: Use of the Chick Embryo Model in Uveal Melanoma

Animal models play a crucial role in basic and translational oncology research. Conventional rodent experiments, however, face ethical, practical and technical issues that limit their use. The chick embryo represents an accessible and economical in vivo model, which has long been used in developmental biology and for the study of angiogenesis. It is also a recognised xenograft model, and because of its lack of immune system in early development, the chick embryo has established itself as a key model system for cancer research, with which to study various steps in the metastatic process. In this chapter, we review the chick embryo model and the technical approaches adopted by cancer biologists, including advances in real-time imaging, and discuss how this has been or can be applied to improve our understanding of the biological events during uveal melanoma development and metastasis.

动物模型在基础与转化肿瘤学研究中发挥着至关重要的作用。然而，传统啮齿类动物实验面临伦理、实践与技术层面的多重局限，制约了其应用推广。鸡胚（chick embryo）是一种易于获取且成本低廉的体内（in vivo）模型，长期以来被应用于发育生物学与血管生成（angiogenesis）研究领域。同时，它也是一种公认的异种移植（xenograft）模型；由于其发育早期缺乏免疫系统，鸡胚已成为癌症研究的核心模型体系，可用于解析肿瘤转移过程中的多个关键环节。在本章节中，我们将对鸡胚模型及癌症生物学家所采用的技术手段（包括实时成像技术的最新进展）进行综述，并探讨该模型已被或可被如何应用，以加深我们对葡萄膜黑色素瘤（uveal melanoma）发生发展及转移过程中生物学事件的理解。