RNA Sequencing of Cardiac in STZ-induced Rat model Uncovers Potential Target of Diabetic cardiomyopathy

Diabetic cardiomyopathy (DCM) is one of the major causes of heart failure in diabetic patients, but its pathogenesis remains unclear. Long non-coding RNAs (lncRNAs) are involved in the development of various cardiovascular diseases, but is little known in DCM. We build diabetic cardiomyopathy (DCM) rat model and investigated the genome-wide expression profiling of cardiac lncRNAs and mRNAs in rat model with and without DCM by RNA sequencing, to uncovers potential path mechanisms target of DCM.糖尿病心肌病（Diabetic cardiomyopathy, DCM）是糖尿病患者发生心力衰竭的主要病因之一，但其发病机制尚未明确。长链非编码RNA（Long non-coding RNAs, lncRNAs）参与多种心血管疾病的发生发展，但目前关于其在糖尿病心肌病中的作用仍知之甚少。本研究构建了糖尿病心肌病（DCM）大鼠模型，并通过RNA测序技术对伴与不伴DCM的大鼠模型心肌组织开展全基因组长链非编码RNA与mRNA表达谱分析，以期揭示糖尿病心肌病潜在的致病机制与治疗靶点。