Metadata record for the article: Whole-exome sequencing identifies somatic mutations and intratumor heterogeneity in inflammatory breast cancer

<b>Summary</b><br> This metadata record provides details of the data supporting the claims of the related article: “Whole-exome sequencing identifies somatic mutations and intratumor heterogeneity in inflammatory breast cancer”. The related study aimed to obtain a better understanding of the genomic landscape and intratumour heterogeneity (ITH) in inflammatory breast cancer (IBC) by conducting whole-exome sequencing of 16 tissue samples (12 tumour and four normal) from six hormone-receptor positive IBC patients, analysing somatic mutations and copy number aberrations, and inferring subclonal structures to demonstrate ITH. Type of data: whole exome sequencing Subject of data: <i>Homo sapiens</i> Sample size: 6 Population characteristics: The participants' demographic and clinical characteristics including age, gender, hormone receptors status, HER2 status, tumour grade were collected. Recruitment: Patients in the discovery cohort were recruited from Thomas Jefferson University Hospital from 1993 to 2012. All the patients were IBC patients. <b>Data access</b> Release of full genetic sequencing data was not included in the IRB protocol. Thus, only sequencing data related to the related article have been released, and these data have been deposited in NCBI <i>Sequence Read Archive</i> (SRA) with the accession code https://identifiers.org/ncbi/bioproject:PRJNA713359. Additional files underlying the figures and supplementary figures of the related article are available as part of this <i>figshare </i>data record, and a list of which file underlies which figure/supplementary figure is included in the file ‘Luo_et_al_2021_underlying_data_files_list.xlsx’. <b>Corresponding author(s) for this study</b> Hushan Yang, PhD, Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Tel: [phone]; Fax: [phone]; Email: [e-mail]. <br> <b>Study approval </b> This study was approved by the Institutional Review Board of Thomas Jefferson University.

<b>摘要</b><br>本元数据记录详细说明了支撑相关论文《全外显子组测序（whole-exome sequencing）鉴定炎性乳腺癌（inflammatory breast cancer，IBC）中的体细胞突变与肿瘤内异质性》结论的数据集详情。相关研究通过对6名激素受体阳性炎性乳腺癌患者的16份组织样本（12份肿瘤组织与4份正常组织）开展全外显子组测序，分析体细胞突变与拷贝数变异，并推导亚克隆结构以阐明肿瘤内异质性，旨在深化对炎性乳腺癌基因组图谱与肿瘤内异质性的认知。<br>数据集类型：全外显子组测序<br>数据研究对象：<i>智人（Homo sapiens）</i><br>样本量：6<br>研究人群特征：收集了受试者的人口学与临床特征，包括年龄、性别、激素受体状态、HER2状态以及肿瘤分级。<br>受试者招募：本研究发现队列的患者于1993年至2012年间从托马斯·杰斐逊大学医院招募，所有受试者均为炎性乳腺癌患者。<br><b>数据获取</b><br>完整基因测序数据的释放在本研究的伦理审查委员会（IRB）方案中未被涵盖。因此，仅发布了与相关论文相关的测序数据，这些数据已提交至美国国家生物技术信息中心（NCBI）的<i>序列读取档案（Sequence Read Archive，SRA）</i>，登录号为https://identifiers.org/ncbi/bioproject:PRJNA713359。支撑相关论文正文图与补充图的额外文件已作为本<i>figshare</i>数据集记录的一部分提供，文件‘Luo_et_al_2021_underlying_data_files_list.xlsx’中列明了各文件对应的图表与补充图。<br><b>本研究通讯作者</b><br>杨沪山（Hushan Yang），哲学博士，任职于美国宾夕法尼亚州费城19107托马斯·杰斐逊大学西德尼·金梅尔癌症中心肿瘤内科。电话：215-503-6521；传真：215-503-9506；邮箱：[e-mail]。<br><b>研究伦理审批</b><br>本研究已通过托马斯·杰斐逊大学伦理审查委员会审批。