BRWD1 binds SMARCA4

BRWD1 (WDR9) is a nuclear protein with eight WD repeats at the N-terminus and 2 centrally located bromodomains. BRWD1 is thought to be involved in chromatin remodelling and transcriptional regulation. BRWD1 binds to Transcription activator BRG1 (SMARCA4 or BRG1), a component of the SWI/SNF complex(Huang et al. 2003). Similar to BRWD1 (Mandal et al. 2015), SMARCA4 is also implicated in B-cell development (Choi et al. 2012, Bossen et al. 2015).

BRWD1（WDR9）是一种定位于细胞核的蛋白，其N端含有八个WD重复序列，并在中心位置具有两个溴结构域。据推测，BRWD1参与染色质重塑和转录调控过程。BRWD1能够与转录激活因子BRG1（SMARCA4或BRG1），SWI/SNF复合体（Huang et al. 2003）的组成成分相结合。与BRWD1（Mandal et al. 2015）相似，SMARCA4亦与B细胞发育（Choi et al. 2012, Bossen et al. 2015）相关。